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Effect of Dietary Sodium Gluconate on Growth

        We examined the effect of Sodium Gluconate (GNA) on the growth performance, the protection against challenge with pathogenic Escherichia coli and the fecal malodor repression in piglets. Either a formula diet containing GNA at 0.5% (w/w) or drinking water containing GNA at 200 mg/kg/day was offered to 18 piglets for 8 weeks to evaluate the effect of GNA on the growth performance. Body weight gain and feed conversion of the piglets treated with GNA were 118, 119% and 92, 95% to the control, respectively. Twenty weaning piglets of 28 days old were used to evaluate the protective effect of dietary GNA against enteric bacterial pathogen. Piglets received a formula diet containing GNA at 0.25, 0.5 or 1.0% (w/w) throughout the experiment. E.coli strain KP-3 was orally administrated to the piglets 7 days after the beginning of the GNA feeding and the number of administrated pathogen was determined 7 days after the challenge. Body weight gain and feed conversion were also determined. GNA decreased challenge bacteria in rectal feces and in the ileal contents. Rectal feces were collected from 8 weaned piglets fed on a formula diet containing 0.5% (w/w) GNA for 2 weeks to evaluate the odor index, odorant compounds such as short-chain fatty acids (SCFA), hydrogen sulfide, and ammonia of feces. GNA reduced odor index, hydrogen sulfide, and ammonia production from feces. (author abst.)